The effects of methiopropamine are usually compared to methamphetamine, but there are too few experience reports with reliably sourced material to say much else with confidence. Described by some as a fairly clean stimulant effect at lower dosages. Negative side effects and difficult come-down period are significantly worse with higher doses and/or redosing multiple times.

It is not yet known how addictive or likely methiopropamine is to cause long-term compulsive use. Many reports describe it as "more-ish", indicating it induces compulsive re-dosing in some users, but not as badly as MDPV or mephedrone. Because its use is so new and uncommon, no definitive statements about it can be made.