Methiopropamine is unscheduled in the United States. It is possible that it could be considered an analog (of methamphetamine), but it does not contain a benzene ring and the 5-member ring contains sulfur, rendering it questionable whether it qualifies as "substantially similar to the chemical structure" of methamphetamine. All Federal Analogues are determined in court and threat of prosecution is a real possibility if a drug is sold for recreational use. We are unaware of any cases against individuals for possession alone.

In one article published by the DEA in 2011, the authors claim that "Although it is claimed to be legal, it is a 2-thienyl analog of the Schedule II controlled substance, methamphetamine, and may be controlled within the United States." See Methiopropamine: An Analytical Profile, by Casale JF, Hayes PA (2011)