Threshold dose when vaporized is between 10 and 50 micrograms. Marked effects occur at 150 to 300 micrograms, vaporized. Effects commence within seconds, peak in about a minute, and diminish rapidly after about five minutes, similar to salvinorin A. However, unlike with smoked or vaporized salvinorin A, minor effects are still noticeable at the half-hour point. Effects reported at doses of 100 to 200 micrograms include: spoked geometric closed- and open-eye visions, alterations in perspective, and palinopsia ("trails" or pronounced afterimages). At higher doses of up to 400 micrograms, effects reported include mental confusion, derealization, and more vivid geometric visions. A sense of "foreboding" has been reported at both lower and higher doses. The effects appear to be similar to those produced by salvinorin A, although one individual experienced with both compounds expressed the opinion that s/he would be able to distinguish between the two.2