Thomas Lyttle was the publisher and editor of Psychedelic Monographs and Essays, a periodical that provided information to the counterculture at a time when mainstream publishing on the topic of illicit psychoactive drugs had slowed to a crawl. The first issue came out in the autumn of 1985, and the sixth and final issue appeared in 1993. PM&E evolved out of the newsletter the Psychozoic Press--An Informational Advisory and Communications Exchange Paper on Psychedelics, which first appeared in 1982. Editor Elvin D. Smith produced ten issues of the Psychozoic Press, and he continued to provide editorial input for PM&E until his death in 1988. Following the conclusion of Lyttle's run as an editor and publisher, he created a "best of" compilation using selections from PM&E, titled Psychedelics: A Collection of the Most Exciting New Material on Psychedelic Drugs. Published by Barricade Books Inc. in 1994, Psychedelics saw wider distribution than PM&E had seen. The final book Lyttle edited was Psychedelics Reimagined, which contained writings by folks like Timothy Leary, Hakim Bey, Otto Snow, Chris Bennett, John W. Allen, Jochen Gartz, and others.

Lyttle was an early collector and producer of LSD blotter art. He is the person who first conceived of asking psychedelic celebrities like Albert Hofmann and Timothy Leary to autograph undipped sheets of blotter. This action inspired increased interest of blotter as an art form. Signed blotter became highly collectible, with rare sheets selling for hundreds or thousands of dollars. Before his death, Lyttle donated some of his more valuable pieces of blotter art to the Multidisciplinary Association for Psychedelic Studies, and the sale of autographed blotter raised around $20,000 for MAPS.