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Bitsch A, Thiel A, Rieckmann P, Prange H.
“Acute inflammatory CNS disease after MDMA ('ecstasy')”.
Eur Neurol. 1996;36(5):328-9.
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Abstract
The amphetamine derivative (+/-)3,4-methylenedioxymethamphetamine (MDMA,'ecstasy', 'Adam') (fig. 1) has emerged as a popular drug of abuse over the last two decades. MDMA produces a mixture of central stimulant and psychedelic effects, many of which are mediated by the neurotransmitters dopamine and serotonin [1]. There has been a recent increase in case reports on serious side effects such as psychiatric disorders (panic attacks, depression, paranoid psychoses, flashbacks, catatonic stupor), neurologic diseases (seizures, intracerebral haemorrhage, sinus venous thrombosis, cerebral infarction) and complications outside the nervous system (disseminated intravasculax coagulation, fulminant hyperthermia, rhabdo myolysis, acute renal failure, gastro-intestinal haemorrhage, acute hepatitis, impaired liver function, aplastic anaemia) [2-6]. We present a case of acute inflammatory cerebral disease associated with heavy MDMA misuse.
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