Erowid References Database
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Bergen JR, Pincus GG.
“Steroid suppression of LSD induced behavior changes in rats”.
Federation Proc.. 1960;19:20.
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Abstract
LSD produces qualitative and quantitative impairment of performance in trained rats. Various steroids (1 mg. i.p.) were administered for 4 days and 40 mcg. LSD were injected 1 hour after the last dose. Significant suppression of the LSD effect was produced by dehydroisoandrosterone, progesterone, testosterone, A5- pregnenolone, 11-desoxycorticosterone, androsterone, etiocholanolone and compounds A, B and S. . "Winter and Flataker (see 199) reported that LSD produces qualitative and quantitative impairment of function in trained rats. We have used their method to test the effectiveness of various steroids to suppress this action of LSD. One mg. quantities of steroids were administered i.p. in 0.25 ml. of a vehicle containing 250ropylene glycol, 75aline for three days. On the fourth day the steroid was given to each rat 1 hour before the injection of 40 mcg. LSD. Rats injected only with the vehicle and LSD were tested simultaneously with the steroid and LSD-treated rats, the former group providing reference values for rating the effectiveness of each steroid. Significant suppression was produced by dehydroisoandrosterone, progesterone, testosterone, A5-pregnenolone, 11-desoxycorticosterone, androsterone, etiocholanolone, and Compounds A, B and S. Other naturally-occurring steroids tested were not effective against LSD."
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