Erowid References Database
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Adolph AR.
“Putative Synaptic Mechanisms Of Inhibition In Limulus Lateral Eye”.
J. gen. Physiol.. 1976;67(4):417-431.
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Abstract
SEROTONIN (5 HT) PERFUSION OF A THIN SECTION OF LIMULUS LATERAL EYE HYPERPOLARIZES RETINULAR AND ECCENTRIC CELL MEMBRANE POTENTIAL, AND BLOCKS SPIKE ACTION POTENTIALS FIRED' BY THE ECCENTRIC CELL. THE INDOLEAMINE DOES NOT' DIRECTLY AFFECT RETINULAR CELL RECEPTOR POTENTIAL OR ECCENTRIC CELL GENERATOR POTENTIAL IN RESPONSE TO LIGHT STIMULI- PERFUSION BLOCKS BOTH THIS INHIBITORY ACTION OF 5-HT AND LIGHT EVOKED' SYNAPTICALLY MEDIATED' LATERAL' INHIBITION. -IONTOPHORETIC APPLICATION OF HT TO THE SYNAPTIC -NEUROPIL PRODUCES SHORTER LATENCY AND DURATION AND-LARGER AMPLITUDE OF INHIBITION THAN DOES THE PERFUSION TECHNIQUE. THIS INHIBITION' IS DOSE DEPENDENT; THE ACCOMPANYING INHIBITORY POSTSYNAPTIC POTENTIAL (IPSP) APPEARS TO HAVE AN EQUILIBRIUM POTENTIAL MORE HYPERPOLARIZED THAN' NORMAL RESTING POTENTIAL LEVELS OF CA. -50 MV. IPSP AMPLITUDE IS SENSITIVE TO EXTRACELLULAR-POTASSIUM ION CONCENTRATION: IT INCREASES WITH DECREASED (K+)O AND DECREASES WITH 'INCREASED IK+30. LSD BLOCKS THE INHIBITION PRODUCED BY IONTOPHORETIC APPLICATION OF 5 HT. INTERACTION BETWEEN LIGHT EVOKED, NATURAL SYNAPTIC TRANSMITTER MEDIATED IPSP'S AND 5 HT IPSP'S-SUGGEST A COMMON POSTSYNAPTI -C RECEPTOR OR TRANSMITTER RECEPTOR PERMEABILITY CHANGE MECHANISM.
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