Erowid.org: Erowid Reference 3231 : Disaggregation of brain polysomes after administration of d-lysergic acid diethylamide (LSD) in vivo : Holbrook L, Brown IR

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Holbrook L, Brown IR. “Disaggregation of brain polysomes after administration of d-lysergic acid diethylamide (LSD) in vivo”. Journal of Neurochemistry. 1976;27:77-82. <a name="ref">Holbrook L, Brown IR.</a> <a href="/references/3231">"Disaggregation of brain polysomes after administration of d-lysergic acid diethylamide (LSD) in vivo"</a> <i>Journal of Neurochemistry</i>. 1976;27:77-82.
Text Abstract (this page) Abstract / Summary - English (482 K) Show Articles by Holbrook L Brown IR Article IDs LSDID: 2981 Erowid RefID: 3231 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract Polysomes from three major brain regions of the young rabbit were disaggregated after in vivo administration of d-LSD. The effect was transient and demonstrated maximal shift after 30-60 min with a return to normal levels by 4 h. Brain polysome disaggregation was elicited by LSD dosages of either 10 or 100 mcg/kg body wt. The polysome shift was not caused by RNase degradation and during maximal disaggregation there was a measurable decrease in protein synthesis.
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