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Jacobs BL, Trulson ME, Stern WC.
“Behavioral Effects Of LSD In The Cat: Proposal Of An Animal Behavior Model For Studying The Actions Of Hallucinogenic Drugs”.
Brain Res.. 1977;132:301- 314.
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Abstract
In the course of examining the complete dose-response relationship for the behavioral effects of LSV in tle cat, we discovered that, in addition to large increases in investigatory and hallucinatory-like responses, two behaviors, not preciously reported, are emitted with a Leigh probability under LSD. Beginning from a baseline of essentially zero in saiine-treatcd animals, limb flicks and abortive grooming increase in frequency in dircc; relation to the close of LSD administered (2.5, 10, 25 and 50 mcg/kg i.p.) and then decrease at higher doses (100 and 200 mcg/kg).. Limb flicks are a species specific behavior seen in normal cats almost exclusively if a response to the presence of a foreign substance, such as water, on the lid paw or forepaw. In abortive grooming the cat orients to the body surface as if to groom lout does not emit the consummatory grooming response (bite, lick or scratch), or emits the response in midair. these behaviors can serve as an animal behavior model for the actions of LSD and related hallucinogens in humans. The specificity of these behavioral changes is indicated by the fact that they are never seen in response to other classes of psychoactive drugs such as D-amphetamine, atropine, caffeine and chlorpheniranine. They are, however, elicited by compounds such as psilocybin which are structurally and functionally related to LSD. The validity of the motlel is based on evidence indicating that it is: specific to hallucinogens, dose dependent, observed in a dose range effective in humans, parallels the major parameters of the actions of LSD in humans (see following palmer) sensitive, robust, reliable, quantifiable and easy to score.
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