Erowid References Database
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Silverman PB, Ho BT.
“Stimulus Properties of DOM: Commonality with Other Hallucinogens”.
Psychopharmacology. 1978;58(2):10.
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Abstract
Rats were trained to discriminate saline from 0.75 and, subsequently 0.5 mg/kg of 2,5-dimethoxy-4-methylamphetamine (DOM) in a 2-lever operant procedure. Food reinforcement was provided on a fixed ratio 20 (FR 20) schedule. Acquisition and test scores consisted of the number of responses on the lever paired with DOM administration, out of the first 20 total responses. Administration of the serotonin antagonist, cinanserin (5.0 mg/kg 15 min pretreatment), blocked the stimulus provided by DOM, without affecting performance following saline treatment. Administration of low doses of (+)-amphetamine (THC) or phencyclidine reulted in predominantly saline-appropriate responses, while higher doses of theae compounds eliminated respondina altogether. Administration of 2,5-dimethoxy-4-ethylamphetamine (DOET), LSD, meacaline, or psilocybin resulted in a majority of responses on the lever paired with DOM in training. The generalization produced by DOET, LSD, mescaline and psilocybin was abolished by cinanserin pretreatment. The results suggest that these compounds produce their discriminable effects by action at a common receptor site.
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