Erowid References Database
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Cassels BK, Gómez-Jeria JS.
“A reevaluation of psychotomimetic amphetamine derivatives in humans”.
J Psychoactive Drugs. 1985 Apr-Jun 30;17(2):129-30.
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Abstract
Each time a quantitative correlation is sought between relative potencies of psychotomimetic drugs and physical properties or structural parameters, the same set
of human pharmacologic data is used (Shulgin, Sargent & Naranjo 1969). This classic study indicated that a margin of error of ± 25 percent is likely for the activities reported
for one-ring psychotomimetics, but it is clear that this degree of precision can only be reached under very stringent experimental conditions, as discussed by Shulgin (1978). When employed as adjuncts in the psychotherapy of neuroses, the effective doses of some of these substances have been seen to vary much more widely from one patient to another. It is not unusual to find that to obtain some standard desired effect with a particular drug some subjects may require twice the dosage needed by others, more or less independent of body weight. Such clinical information, which could lead to a more generally meaningful assessment of a drug's activity, is seldom found in the literature.
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