Erowid References Database
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Bhattacharyya BJ, Sokoll MD, Long JP.
“Effect of +/--DOI on neuromuscular transmission: a microelectrode study”.
Eur J Pharmacol. 1991 Mar 15;195(1):171-4.
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Abstract
DOI 1-2,5-dimethoxy-4-iodophenyl-2-aminopropane significantly depressed end plate current EPC amplitude. It decreased quantum content, increased the extent of neurally evoked EPC rundown during the train, produced a nonlinear current-voltage relationship, shortened time constant of decay, and depressed iontophoretically evoked EPC. The depressant response of DOI on EPC amplitude was antagonized by 5-HT1-like receptor antagonists, but was resistant to 5-HT2 and 5-HT3 receptor antagonists. This suggests that inhibitory 5-HT receptors roughly correspond to 5-HT1-like receptors.
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