Erowid References Database
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Cheng HC, Long JP, Barfknecht CF, Nichols DE.
“Cardiovascular effects of 2, 5-dimethoxy-4-methylamphetamine DOM, STP”.
J Pharmacol Exp Ther. 1973 Aug 26;186(2):345-54.
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Abstract
A single dose of 2,5-dimethoxy-4-methylamphetamine DOM 246 &305zg/kg produced a
pressor response in vagotomized dogs. There was also an increase in pulse pressure.
Tachyphylaxis developed rapidly after repeated doses of DOM. Responses to tyramine
were not diminished after tacimyphylaxis to DOM developed. DOM also enhanced
pressor responses to norepinephrine, epinephrine and tyramine. In perfused dog fore
limb DOM produced a vasodilation followed by a vasoconstniction. The vasoconstriction
produced by DOM was not blocked by phentolamine but was antagonized by
methysergide. In isolated superfused vascular strips of dog dorsal metatarsal vein, DOM
elicited a muscle contraction which was not blocked by phentolamine or cocaine but
was antagonized by cinanserin. It was concluded that DOM had a direct stimulatory
effect on serotonin receptors. The vasodilation in the perfused fore limb of the dog induced by DOM was not antagonized by propranolol, atropine, pyrilamine or bulbocapnine. In isolated guinea-pig atria, DOM exhibited an antiicotine action and also blocked the inhibitory effect induced by vagus nerve stimulation.
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