Erowid.org: Erowid Reference 8228 : Withdrawal from chronic treatment with ą-DOI causes super-sensitivity to 5-HT2 receptor-induced head-twitch behaviour in mice : Darmani NA, Martin BR, Glennon RA

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Darmani NA, Martin BR, Glennon RA. “Withdrawal from chronic treatment with ą-DOI causes super-sensitivity to 5-HT2 receptor-induced head-twitch behaviour in mice”. Eur J Pharmacol. 1990 Sep 15;186(1):115-8. <a name="ref">Darmani NA, Martin BR, Glennon RA.</a> <a href="/references/8228">"Withdrawal from chronic treatment with ą-DOI causes super-sensitivity to 5-HT2 receptor-induced head-twitch behaviour in mice"</a> <i>Eur J Pharmacol</i>. 1990 Sep 15;186(1):115-8.
Text Abstract (this page) Full Text - English (private) Show Articles by Darmani NA Martin BR Glennon RA Article IDs Erowid RefID: 8228 PubMedID: 2282932 Collections Hofmann Collection MDMA Collection All References	Abstract Mice were injected once daily for 13 days with ą-DOI ą-1-2,5-dimethoxy-4-iodophenyl-2-aminopropane and the induced head-twitch response HTR was scored. On days 2-5 HTR was reduced to less than 50 of day 1, and then returned to control levels by day 13. Challenge doses of ą-DOI administered on days 15, 17 or 19 elicited significantly exaggerated responses. Thus, chronic treatment with ą-DOI may cause an initial down-regulation followed by an up-regulation of 5-HT2 receptor function after cessation of such treatment.
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